Over the summer, this 18-month-old, 28-suite Gold List hotel in Provence welcomed a spa to its 60 acres of vineyards, olive groves, lavender fields and pine forests. The new wellness program boasts a pedigree as impressive as that of the hotel’s design and art, which includes buildings from architects Frank Gehry and Renzo Piano and works by Damien Hirst, among others. Greg Payne, the former spa director of Amanresorts, runs the show here, and he’s assembled an international dream team of top practitioners—an Israeli yogi, a Russian cranio-sacral healer, an Irish meditation master who trained in India—as well as an extensive hydrotherapy space and a tempting treatment menu that makes use of local salt, mud and herbs.

Situated halfway between the historic town of Aix en Provence, home of Cezanne, and the famous Luberon Nature Park, Villa La Coste is set in the midst of the Provencal landscape, in the heart of the biodynamic vineyard Château La Coste, an international destination for art, architecture and natural beauty.